Music track throughout.

TEXT ON SCREEN: YOUR OVERACTIVE IMMUNE SYSTEM

ANNOUNCER VOICE OVER (AVO): With rheumatoid arthritis, your
overactive immune system…

TEXT ON SCREEN: ATTACKS JOINTS

AVO: …attacks joints and may cause inflammation that contributes to
symptoms throughout your body.

TEXT ON SCREEN: RINVOQ^® (upadacitinib)
RINVOQ is a prescription medicine used to treat adults with moderate
to severe rheumatoid arthritis when 1 or more medicines called tumor
necrosis factor (TNF) blockers have been used, and did not work well or
could not be tolerated. It is not known if RINVOQ is safe and effective in
children with juvenile idiopathic arthritis.
Please see Important Safety Information in video and on this web page.
Please see link for the full Prescribing Information, including the
Medication Guide.

 

AVO: That’s where RINVOQ can help. RINVOQ is a prescription
medicine used to treat adults with moderate to severe rheumatoid
arthritis in whom TNF blockers did not work well.

 

TEXT ON SCREEN: GET AN INSIDE LOOK AT HOW IT WORKS

 

AVO: Let’s take a deeper, inside look at how it works in your body.

 

TEXT ON SCREEN: For illustrative purposes only

 

AVO: RINVOQ is a JAK inhibitor that works inside your cells to block
certain signals that are thought to cause inflammation.

 

TEXT ON SCREEN: RINVOQ^® (upadacitinib)
REGULATES & HELPS STOP

 

AVO: RINVOQ regulates your overactive immune system to help stop
the attack.

 

TEXT ON SCREEN: RINVOQ HELPS REDUCE

PAIN
STIFFNESS
SWELLING
RA FATIGUE

 

AVO: Clinical studies have proven RINVOQ helps reduce pain,
stiffness, swelling, and for some it can even significantly reduce RA
fatigue.

 

TEXT ON SCREEN: RINVOQ^® (upadacitinib)

ASK YOUR RHEUMATOLOGIST ABOUT RINVOQ RELIEF

 

AVO: That’s RINVOQ Relief.

 

TEXT ON SCREEN: SAFETY CONSIDERATIONS

 

TEXT ON SCREEN: RINVOQ can lower your ability to fight infections,
including TB. Serious infections and blood clots, some fatal;

 

TEXT ON SCREEN: Do not start RINVOQ if you have an infection.
Before and during treatment your doctor will test for tuberculosis (TB)
and do bloodwork.
Please see additional Important Safety Information on this page.

 

AVO: RINVOQ can lower your ability to fight infections, including TB.
Serious infections and blood clots, some fatal;...

 

TEXT ON SCREEN: cancers, including lymphoma and skin cancer;
death, heart attack, stroke, and tears in the stomach or intestines
occurred.

 

TEXT ON SCREEN: Tell your doctor if you have a history of these
events, any infections, hepatitis B or C, or smoking.
Please see additional Important Safety Information on this page.

 

AVO: ...cancers, including lymphoma and skin cancer; death,
heart attack, stroke, and tears in the stomach or intestines occurred.

 

TEXT ON SCREEN: People 50 and older with at least one heart
disease risk factor have higher risks.

 

TEXT ON SCREEN: People 50 and older with at least 1 heart disease
risk factor are at increased risk for death, heart attack, stroke and blood
clots.
Please see additional Important Safety Information on this page.

 

AVO: People 50 and older with at least one heart disease risk factor
have higher risks.

 

TEXT ON SCREEN: Don’t take if allergic to RINVOQ as serious
reactions can occur. Tell your doctor if you are or may become
pregnant.

 

TEXT ON SCREEN: Get help if you have rash (hives), trouble breathing,
feel faint or dizzy, have swelling of your lips, tongue, or throat.
Please see additional Important Safety Information on this page.

 

AVO: Don’t take if allergic to RINVOQ as serious reactions can occur.
Tell your doctor if you are or may become pregnant.