See how RINVOQ works inside your body
Music track throughout.
Please see RINVOQ Use and Safety Considerations within this video
VO: A garden is an intricate balance of systems working together in harmony.
When that balance is off, the harmony can be upset, and the garden’s health can be affected.
Your body is very much like a garden.
When you’re healthy, inflammation is one of your body’s defenses against things that can hurt you or make you sick.
Ezcema (or atopic dermatitis) is driven by inflammation. With this condition, your immune system is overactive, throwing it off balance.
The result of too much inflammation can be the relentless itch and rash of eczema.
Let’s take a look beneath the surface at overactive immune cells within your skin.
While the exact cause of eczema is unknown, different proteins called cytokines are thought to play a role in the inflammation contributing to symptoms like eczema’s itch and rash.
These cytokines send signals through pathways that use other proteins called Janus kinases, or JAKs, to pass the signals inside your cells.
If you have eczema, these pathways, including JAKs, can be overstimulated. This can contribute to too much inflammation.
RINVOQ is for people 12+ years with moderate to severe atopic dermatitis (AD) who did not respond to previous treatment and are not well controlled using other pills or injections, including biologics.
Please see Important Safety Information, including BOXED WARNING on Serious Infections, Increased Risk of Death, Cancer, Major Cardiovascular Events and Blood Clots in video and on this web page.
When you have too much inflammation, RINVOQ may help regulate your overactive immune system.
RINVOQ is a JAK inhibitor, meaning it works within your immune system to help block the activity of some JAK proteins that are thought to contribute to excess inflammation.
RINVOQ has been proven to help reduce the itch and rash of eczema.
In clinical trials of people with moderate to severe eczema, RINVOQ helped deliver dramatic results—fast.
Some people felt significantly less itch as early as 2 days after their first dose.
Some achieved dramatic skin clearance as early as two weeks.
Many saw clear or almost-clear skin.
And some saw 100% skin clearance.
In another study of RINVOQ, many patients had clearer skin and less itch, even at 3 years.
Interested in RINVOQ? Talk to your doctor today.
RINVOQ USE
RINVOQ is a prescription medicine used to treat adults and children 12 years of age and older with moderate to severe eczema (atopic dermatitis) that did not respond to previous treatment and their eczema is not well controlled with other pills or injections, including biologic medicines, or the use of other pills or injections is not recommended. It is not known if RINVOQ is safe and effective in children under 12 years of age with atopic dermatitis.
Individual results may vary.
Please see Safety Considerations within this video.
Safety Considerations
RINVOQ (upadacitinib) may cause serious side effects, including:
- Serious infections. RINVOQ can lower ability to fight infections. Serious infections, some fatal, occurred, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Cancer and immune system problems. Increased risk of some cancers, including lymphoma and skin. Current or past smokers have higher risk for lymphoma and lung cancer.
- Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Blood clots, some fatal, in veins of the legs or lungs and arteries. This occurred more often in people 50+ with at least 1 heart disease risk factor.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
- Tears in the stomach or intestines; changes in certain laboratory test results.
Please see additional Important Safety Information on this page and link to Prescribing Information.