For adults with moderate to severe Crohn’s disease in whom TNF blockers did not work well

How RINVOQ Works video transcript

Music track throughout.

VOICEOVER (VO): Crohn’s disease,

VO: also known as Crohn’s,

VO: is a condition where chronic inflammation damages your gastrointestinal tract.

VO: This can contribute to symptoms including abdominal pain, more frequent bowel movements, and fatigue.

VO: You may be used to thinking of inflammation as redness or swelling. When you’re healthy, inflammation is one of your body’s defenses against things that can hurt you or make you sick.

VO: But there is such a thing as too much inflammation. That’s the case with Crohn’s, where the GI tract gets inflamed even when your body doesn’t need the protection.

VO: Inflammation can build up, potentially damaging your GI tract.

VO: With Crohn’s, you may be wondering why your immune system doesn’t know when to stop making inflammation. Let’s take a look.

VO: Your body has many natural pathways involved in inflammation. They pass along information to help your immune system figure out when and where inflammation should happen.

VO: One of those pathways involves proteins known as Janus kinase, or JAK proteins. They can be found inside your body’s immune cells.

VO: With Crohn’s, some JAK proteins receive too many signals, causing your immune system to create too much inflammation. This inflammation can build up, causing more damage over time.

VO: RINVOQ is a prescription medicine used to treat adults with moderate to severe Crohn’s disease when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well or could not be tolerated. It is not known if RINVOQ is safe and effective in children with Crohn’s disease.

VO: RINVOQ is a JAK inhibitor that helps stop the activity of some JAK proteins.

VO: RINVOQ helps stop the attack by reducing these signals that lead to excess inflammation.

VO: RINVOQ is a once-daily pill that travels through the bloodstream that can reduce inflammation to help decrease symptoms and give your intestinal lining the chance to achieve visibly reduced damage.

VO: In clinical studies, RINVOQ was proven to help people achieve rapid symptom relief, the opportunity to be in early remission without steroids, visibly reduced damage of the intestinal lining caused by excess inflammation, and significantly reduced fatigue.

VO: Ask your gastroenterologist if RINVOQ is right for you.


RINVOQ may cause serious side effects, including:

  • Serious infections. RINVOQ can lower ability to fight infections. Serious infections, some fatal, occurred, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
  • Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
  • Cancer and immune system problems. Increased risk of some cancers, including lymphoma and skin. Current or past smokers have higher risk for lymphoma and lung cancer.
  • Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
  • Blood clots, some fatal, in veins of the legs or lungs and arteries. This occurred more often in people 50+ with at least 1 heart disease risk factor. 
  • Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
  • Tears in the stomach or intestines; changes in certain laboratory test results.

TEXT ON SCREEN: Please see additional Important Safety Information on this page and link to Prescribing Information.