What is

RINVOQ? (upadacitinib) 15mg tablets

For adults with moderate to severe rheumatoid arthritis (RA) in whom TNF blockers did not work well. 

The science of how RINVOQ for RA works

RINVOQ is a JAK (Janus kinase) inhibitor that regulates your overactive immune system and works inside your cells to block certain signals that are thought to cause inflammation.

What is a JAK inhibitor, and how does it work?


Cytokine in a cell.

Proteins called cytokines are believed to cause inflammation, contributing to RA symptoms

JAK pathway receiving too many signals and causing inflammation.

Cytokines can send messages into your cells by communicating with JAKs—this creates what is known as a pathway

Inflammation on the cell from overactive JAK pathway leading to too much inflammation from the immune system.

With RA, these JAK pathways receive too many signals, creating too much inflammation from the immune system

RINVOQ attached to a JAK and lowering inflammation by blocking the JAK pathways.

RINVOQ helps regulate your immune system by helping block JAK pathways


Because JAK inhibitors, including RINVOQ, affect the immune system, they can lower the ability to fight infections and may cause other serious side effects. It’s important to talk to your healthcare provider about the possible side effects of prescription treatments. Learn more >

"When I had tried other medications like HUMIRA® and ENBREL®, and they just couldn’t manage all of my symptoms, I really wanted to try something

— Elizabeth, RINVOQ patient

Different.”

RINVOQ is a JAK inhibitor

— Elizabeth, RINVOQ patient

Already tried one TNF blocker and still have RA symptoms? Permanent joint damage can be happening now. Don't wait until it's too late. Ask your doctor if RINVOQ, a once-daily pill, is right for you.

Have you previously or currently been prescribed a TNF blocker like HUMIRA® or ENBREL® for your moderate to severe RA?

HUMIRA® is a registered trademark of AbbVie Inc. ENBREL® (etanercept) is a registered trademark of Immunex Corporation in the US.

NEXT PAGE