For adults with active ankylosing spondylitis (AS) in whom TNF blockers did not work well.

RINVOQ is a once-daily pill. See it in action.

How does RINVOQ work in the body?

With ankylosing spondylitis (AS), your overactive immune system mainly attacks your spine and may cause inflammation that contributes to back pain and stiffness.

RINVOQ is a JAK (Janus kinase) inhibitor that regulates your overactive immune system to help stop the attack. It works inside your cells to block certain signals that are thought to be an underlying cause of AS inflammation.

JAK Inhibitors for ankylosing spondylitis

Because JAK inhibitors, including RINVOQ, affect the immune system, they can lower the ability to fight infections and may cause other serious side effects. It's important to talk to your healthcare provider about the possible side effects of prescription treatments.

When is the right time to ask for RINVOQ?

If you’re still experiencing AS symptoms after a TNF blocker like HUMIRA® or ENBREL®, RINVOQ, a JAK inhibitor, is different and may help.

For more information, talk to your doctor or learn more about the Most Important Safety Information of RINVOQ >

Man tying kayak to car.
RINVOQ® (upadacitinib) pill.

See the results of RINVOQ, a once-daily pill

RINVOQ can significantly relieve back pain and stiffness, and improve your ability to do everyday activities.

Before you and your doctor make a treatment decision, read about the Use and Important Safety Information below.

and talk to your rheumatologist.


ENBREL® (etanercept) is a registered trademark of Immunex Corporation.