WITH ACTIVE
ANKYLOSING
SPONDYLITIS
For adults with active ankylosing spondylitis (AS) in whom TNF blockers did not work well.
About ankylosing spondylitis (AS)
AS is a chronic (ongoing) condition. That means symptoms may keep coming back and last a long time. Once someone has AS, they may always have it. Although the causes of AS are unknown, it's possible that environment, different stressors, and family history may play a role. AS can be passed down through the HLA-B27 gene. Taking a blood test may detect this protein and help make a diagnosis.
Back of body
What is inflammation?
AS is a chronic inflammatory disease that primarily affects the spine. When you have AS, an immune system response causes inflammation in healthy joints. The inflammation contributes to pain and stiffness.
Inflammation is your body's normal response to protect against something your immune system thinks will cause harm. When excess inflammation doesn't go away, it can lead to conditions including AS.
Prolonged inflammation can lead to the following symptoms
When you are living with AS, the inflammation does not go away over time. This can lead to the following symptoms:
- Spine stiffness that is usually worse in the morning and at night
- Back pain and stiffness that get worse with inactivity and better with physical activity
- Pain and stiffness in alternating sides of the body—starting at the lower back and buttocks
- Symptoms lasting more than 3 months
Taking RINVOQ
It’s important to remember that AS is a chronic, or ongoing, condition. Taking RINVOQ as prescribed is important as AS can persist even though you don’t have symptoms.
RINVOQ must be taken exactly as prescribed by your doctor
- Take RINVOQ once a day, every day
- RINVOQ can be taken with or without food. Avoid food or drink containing grapefruit
- Do not split, crush, or chew the pill
Call your healthcare provider if you see medication residue (a whole tablet or tablet pieces) in your stool.
What should you do if you miss a dose?
- Call the doctor about the missed dose
- Set up a visual cue or reminder that will help you remember to take RINVOQ
- Use treatment reminders and fill out your treatment log in the RINVOQ Complete App, so you’ll know when/if you have taken RINVOQ
Check in with the doctor
Regular check-ins and open discussions with the doctor can help you stay on track with a prescribed treatment plan.
Track symptoms
Use the RINVOQ Complete App to keep track of symptoms and share them with your doctor.
How RINVOQ works
With AS, an overactive immune system may cause excess inflammation, contributing to symptoms like back pain and stiffness. RINVOQ helps regulate your overactive immune system and works inside your cells to block certain signals that are thought to cause inflammation.
Because JAK inhibitors, including RINVOQ, affect the immune system, they can lower the ability to fight infections and may cause other serious side effects. It's important to talk to your healthcare provider about the possible side effects of prescription treatments.
Transcript
Music track throughout.
TEXT ON SCREEN: YOUR OVERACTIVE IMMUNE SYSTEM
ANNOUNCER VOICE OVER (AVO): With ankylosing spondylitis, or AS, your overactive immune system...
TEXT ON SCREEN: ATTACKS SPINAL JOINTS
AVO: ...attacks mainly spinal joints and may cause inflammation that contributes to other symptoms throughout your body, such as in the hips, neck, and shoulders.
TEXT ON SCREEN: RINVOQ® (upadacitinib)
RINVOQ is a prescription medicine used to treat adults with active ankylosing spondylitis when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well or could not be tolerated. It is not known if RINVOQ is safe and effective in children with ankylosing spondylitis.
Please see Important Safety Information in video and on this web page. Please see link for the full Prescribing Information, including the Medication Guide.
AVO: That's where RINVOQ comes in. RINVOQ is a prescription medicine for adults with active ankylosing spondylitis (AS) in whom TNF blockers did not work well.
TEXT ON SCREEN: GET AN INSIDE LOOK AT HOW IT WORKS
AVO: Let's take a deeper, inside look at how it works in your body.
TEXT ON SCREEN: For illustrative purposes only
AVO: RINVOQ is a JAK inhibitor that works inside your cells to block certain signals that are thought to cause inflammation.
TEXT ON SCREEN: RINVOQ® (upadacitinib)
REGULATES & HELPS STOP
AVO: RINVOQ regulates your overactive immune system to help stop the attack.
TEXT ON SCREEN: RINVOQ HELPS RELIEVE AS
AVO: A clinical study has proven RINVOQ helps relieve AS...
TEXT ON SCREEN: RINVOQ HELPS RELIEVE AS
BACK PAIN & STIFFNESS
AVO: ...back pain and stiffness.
TEXT ON SCREEN: RINVOQ® (upadacitinib)
ASK YOUR RHEUMATOLOGIST ABOUT RINVOQ RELIEF
AVO: That's RINVOQ relief
TEXT ON SCREEN: RINVOQ® (upadacitinib)
SAFETY CONSIDERATIONS
RINVOQ may cause serious side effects, including:
- Serious infections. RINVOQ can lower ability to fight infections. Serious infections, some fatal, occurred, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Cancer and immune system problems. Increased risk of some cancers, including lymphoma and skin. Current or past smokers have higher risk for lymphoma and lung cancer.
- Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Blood clots, some fatal, in veins of the legs or lungs and arteries. This occurred more often in people 50+ with at least 1 heart disease risk factor.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
- Tears in the stomach or intestines; changes in certain laboratory test results.
Please see additional Important Safety Information on this webpage.
AVO: Safety considerations. RINVOQ may cause serious side effects, including:
- Serious infections. RINVOQ can lower ability to fight infections. Serious infections, some fatal, occurred, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Cancer and immune system problems. Increased risk of some cancers, including lymphoma and skin. Current or past smokers have higher risk for lymphoma and lung cancer.
- Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Blood clots, some fatal, in veins of the legs or lungs and arteries. This occurred more often in people 50+ with at least 1 heart disease risk factor.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
- Tears in the stomach or intestines; changes in certain laboratory test results.
Please see additional Important Safety Information on this webpage.
Select Important Safety Information
RINVOQ may cause serious side effects, including:
- Serious Infections, Cancer and Immune System Problems, and Blood Clots.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Increased risk of major cardiovascular events, such as heart attack, stroke, or death in people age 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
See full Important Safety Information below.
Set reminders
Use the App to set medication reminders and track doses.
RINVOQ results
In a clinical study, RINVOQ helped:
- Many people achieve significant relief from AS back pain and stiffness in 14 weeks vs placebo (44.5% vs 18.2%). Some saw improvement as fast as 4 weeks
- Increase functional mobility, making it easier to do everyday activities
- Improve quality of life for AS patients
- Give people nights with less back pain for better days ahead
Understanding the possible side effects of RINVOQ
Always consider the benefits and risks of taking RINVOQ and discuss with your doctor.
Get 1-to-1 support from your RINVOQ Complete Nurse Ambassador*
Reach out when you need answers. Just call 1.800.2RINVOQ (1.800.274.6867).
*Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.
Build a routine with the
RINVOQ
Complete App
- Use medication reminders and track your doses so you know when/if you’ve taken your medicine
- Log and share symptoms with your doctor
- Set personal goals to help you manage your condition,
track your progress, and stay motivated
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