WITH ACTIVE nr-axSpA
WITH ACTIVE nr-axSpA
For adults with active non-radiographic axial spondyloarthritis with objective signs of inflammation in whom a TNF blocker did not work well.
About non-radiographic axial spondyloarthritis (nr-axSpA)
Nr-axSpA is a chronic (ongoing), inflammatory condition. Once someone has nr-axSpA, they may always have it. Although the causes of nr-axSpA are unknown, it's possible that environment, different stressors, and family history may play a role. Nr-axSpA can be passed down through the HLA-B27 gene. Taking a blood test may detect this protein and help make a diagnosis.
Back of body
What is inflammation?
Nr-axSpA is a chronic inflammatory condition that primarily affects the spine. It can lead to inflammation that may cause back pain and stiffness.
Inflammation is your body’s normal response to protect against something your immune system thinks will cause harm. When excess inflammation caused by your immune system doesn’t go away, it can lead to conditions like nr-axSpA.
How the immune system triggers inflammation
It is believed that the immune system sends white blood cells to the joints of your spine, causing inflammation. When inflammation doesn’t go away, it can lead to symptoms including:
- Back pain and stiffness that is usually worse with inactivity (especially in the morning and at night)
- Pain and stiffness that improves with physical activity
- Symptoms lasting more than 3 months
Helpful tips for managing nr-axSpA
Here are some steps you can take to help you manage your nr-axSpA symptoms.
Taking RINVOQ
It's important to remember that nr-axSpA is a chronic, or ongoing, condition. Taking RINVOQ as prescribed is important as nr-axSpA can persist even though you don't have symptoms.
RINVOQ must be taken exactly as prescribed by your doctor
- Take RINVOQ once a day, every day
- RINVOQ can be taken with or without food. Avoid food or drink containing grapefruit
- Do not split, crush, or chew the pill
Call your healthcare provider if you see medication residue (a whole tablet or tablet pieces) in your stool.
What should you do if you miss a dose?
- Call the doctor about the missed dose
- Set up a visual cue or reminder to help you remember to take RINVOQ
- Use treatment reminders and fill out the treatment log in the RINVOQ Complete App, so you’ll know when/if you have taken RINVOQ
Check in with the doctor
Regular check-ins and open discussions with the doctor can help you stay on track with a prescribed treatment plan.
Track symptoms
Use the RINVOQ Complete App to keep track of symptoms and share them with your doctor.
How RINVOQ works
With nr-axSpA, your overactive immune system mainly attacks your spine and may cause inflammation that contributes to back pain and stiffness. RINVOQ works to help regulate your overactive immune system and can help reduce the inflammation that contributes to nr-axSpA symptoms.
Because JAK inhibitors, including RINVOQ, affect the immune system, they can lower the ability to fight infections and may cause other serious side effects. It's important to talk to your healthcare provider about the possible side effects of prescription treatments.
Transcript
Music track throughout.
TEXT ON SCREEN: YOUR OVERACTIVE IMMUNE SYSTEM
ANNOUNCER VOICE OVER (AVO): With non-radiographic axial spondyloarthritis, or nr-axSpA, your overactive immune system…
TEXT ON SCREEN: ATTACKS SPINAL JOINTS
AVO: ...attacks mainly spinal joints and may cause inflammation that contributes to other symptoms throughout your body, such as in the hips, neck, and shoulders.
TEXT ON SCREEN: RINVOQ® (upadacitinib)
RINVOQ is a prescription medicine used to treat adults with active non-radiographic axial spondyloarthritis (nr-axSpA) with objective signs of inflammation when a tumor necrosis factor (TNF) blocker medicine has been used, and did not work well or could not be tolerated. It is not known if RINVOQ is safe and effective in children with non-radiographic axial spondyloarthritis.
Please see Important Safety Information in video and on this webpage. Please see link for the Full Prescribing Information, including the Medication Guide, for RINVOQ.
AVO: That's where RINVOQ comes in. RINVOQ is a prescription medicine used to treat adults with active non-radiographic axial spondyloarthritis with objective signs of inflammation when a TNF blocker medicine has been used, and did not work well or could not be tolerated.
TEXT ON SCREEN: GET AN INSIDE LOOK AT HOW IT WORKS
AVO: Let's take a deeper, inside look at how it works in your body.
TEXT ON SCREEN: For illustrative purposes only
AVO: RINVOQ is a JAK inhibitor that works inside your cells to block certain signals that are thought to cause inflammation.
TEXT ON SCREEN: RINVOQ® (upadacitinib)
REGULATES & HELPS STOP
AVO: RINVOQ regulates your overactive immune system to help stop the attack.
TEXT ON SCREEN: RINVOQ HELPS RELIEVE NR-AXSPA
AVO: A clinical study has proven RINVOQ helps relieve nr-axSpA...
TEXT ON SCREEN: RINVOQ HELPS RELIEVE NR-AXSPA
BACK PAIN & STIFFNESS
AVO: ...back pain and stiffness.
TEXT ON SCREEN: RINVOQ® (upadacitinib)
ASK YOUR RHEUMATOLOGIST ABOUT RINVOQ RELIEF
AVO: That's RINVOQ relief.
TEXT ON SCREEN: RINVOQ® (upadacitinib)
SAFETY CONSIDERATIONS
RINVOQ may cause serious side effects, including:
- Serious infections. RINVOQ can lower ability to fight infections. Serious infections, some fatal, occurred, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Cancer and immune system problems. Increased risk of some cancers, including lymphoma and skin. Current or past smokers have higher risk for lymphoma and lung cancer.
- Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Blood clots, some fatal, in veins of the legs or lungs and arteries. This occurred more often in people 50+ with at least 1 heart disease risk factor.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
- Tears in the stomach or intestines; changes in certain laboratory test results.
Please see additional Important Safety Information on this webpage.
AVO: Safety considerations. RINVOQ may cause serious side effects, including:
- Serious infections. RINVOQ can lower ability to fight infections. Serious infections, some fatal, occurred, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Cancer and immune system problems. Increased risk of some cancers, including lymphoma and skin. Current or past smokers have higher risk for lymphoma and lung cancer.
- Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Blood clots, some fatal, in veins of the legs or lungs and arteries. This occurred more often in people 50+ with at least 1 heart disease risk factor.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
- Tears in the stomach or intestines; changes in certain laboratory test results.
Please see additional Important Safety Information on this webpage.
Select Important Safety Information
RINVOQ may cause serious side effects, including:
- Serious Infections, Cancer and Immune System Problems, and Blood Clots.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Increased risk of major cardiovascular events, such as heart attack, stroke, or death in people age 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
See full Important Safety Information below.
Set reminders
Use the App to set medication reminders and track doses.
RINVOQ results
In a clinical study, RINVOQ helped:
- Relieve nr-axSpA back pain and stiffness
- Reduce overall nr-axSpA disease activity, which was measured using a questionnaire about a range of symptoms including: back pain, joint pain and swelling, enthesitis (pain and swelling in areas like the heel and elbow), and morning stiffness
- Improve physical function, making it easier to do everyday activities
- Reduce fatigue that can come from nr-axSpA
Understanding the possible side effects of RINVOQ
Always consider the benefits and risks of taking RINVOQ and discuss with your doctor.
Get 1-to-1 support from your RINVOQ Complete Nurse Ambassador*
Reach out when you need answers. Just call 1.800.2RINVOQ (1.800.274.6867).
*Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.
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