WITH MODERATE TO SEVERE ULCERATIVE COLITIS
WITH MODERATE TO SEVERE ULCERATIVE COLITIS
For adults with moderate to severe ulcerative colitis (UC) in whom TNF blockers did not work well.
About ulcerative colitis (UC)
UC belongs to a larger group of conditions called inflammatory bowel diseases (IBDs). UC is a chronic (ongoing, long-term) condition where inflammation in the large intestine (colon and rectum) can lead to symptoms over time. When you are living with UC, your overactive immune system causes inflammation that leads to more than just symptoms, it damages the colon lining.
Front of body
What is inflammation?
Inflammation is your body’s normal response to protect against something your immune system thinks will cause harm. When excess inflammation caused by your immune system doesn’t go away, it can lead to conditions like UC.
How the immune system triggers inflammation
For people with UC, the immune system mistakenly harms healthy cells in the inner lining of the large intestine or colon, leading to inflammation. Chronic inflammation can contribute to UC symptoms, which may include:
- Sudden accidents or bowel urgency
- Abdominal pain
- Frequent bathroom trips
- Fatigue
- Bloody stools
Taking RINVOQ
It’s important to remember that UC is a chronic, or ongoing, condition. Taking RINVOQ as prescribed is important as UC can persist even though you don’t have symptoms.
RINVOQ must be taken exactly as prescribed by your doctor
- Take RINVOQ once a day, every day
- RINVOQ can be taken with or without food. Avoid food or drink containing grapefruit
- Do not split, crush, or chew the pill
Call your healthcare provider if you see medication residue (a whole tablet or tablet pieces) in your stool.
What should you do if you miss a dose?
- Call the doctor about the missed dose
- Set up a visual cue or reminder to help you remember to take RINVOQ
- Use treatment reminders and fill out your treatment log in the RINVOQ Complete App, so you know when/if you have taken RINVOQ
Check in with your doctor
Regular check-ins and open discussions with the doctor can help you stay on track with a prescribed treatment plan.
Track symptoms
Use the RINVOQ Complete App to keep track of symptoms and share them with your doctor.
How RINVOQ works
RINVOQ works by targeting a source of inflammation caused by a naturally occurring protein called JAK (Janus kinase). RINVOQ works with your body to fight the inflammation that can lead to UC symptoms and colon lining damage.
Because JAK inhibitors, including RINVOQ, affect the immune system, they can lower the ability to fight infections and may cause other serious side effects. It’s important to talk to your healthcare provider about the possible side effects of prescription treatments.
Transcript
Music track throughout.
TEXT ON SCREEN: ULCERATIVE COLITIS
ANNOUNCER VOICE OVER (VO): Ulcerative colitis,
TEXT ON SCREEN: UC
AVO: also known as UC,
TEXT ON SCREEN: UC
A condition where chronic inflammation damages your colon
AVO: is a condition where chronic inflammation damages your colon,
TEXT ON SCREEN: Sudden accidents
Increased bathroom trips
Blood in your stool
Gut pain
AVO: which can lead to symptoms like sudden accidents, increased trips to the bathroom, blood in your stool, and gut pain.
AVO: You may be used to thinking of inflammation as redness or swelling. When you’re healthy, inflammation is one of your body’s defenses against things that can hurt you or make you sick.
AVO: But, there is such a thing as too much inflammation. That’s the case with UC, where the inner lining of your colon gets inflamed even when your body doesn’t need the protection. Inflammation can build up, causing more damage over time.
TEXT ON SCREEN: WITH UC,
you may be wondering why your immune system doesn’t know when to stop making inflammation.
AVO: With UC, you may be wondering why your immune system doesn’t know when to stop making inflammation. Let’s take a look.
AVO: Your body has many natural pathways involved in inflammation. They pass along information to help your immune system figure out when and where inflammation should happen. One of those pathways involves proteins known as Janus kinase, or JAK proteins.
TEXT ON SCREEN: JAK
AVO: With UC, some JAK proteins receive too many signals, causing your immune system to create too much inflammation and start to damage the colon.
TEXT ON SCREEN:
A ONCE-DAILY PILL
for adults with moderate to severe UC in whom TNF blockers did not work well
Pill not actual size
Please see Important Safety Information in video and on this web page.
Please see link for the full Prescribing Information, including the Medication Guide.
AVO: That’s where RINVOQ, a once-daily pill, can help. RINVOQ is a prescription medicine used to treat adults with moderate to severe ulcerative colitis in whom TNF blockers did not work well.
TEXT ON SCREEN: JAK
RINVOQ
AVO: RINVOQ stops the activity of some JAK proteins. That means when you have too much inflammation, RINVOQ can help regulate your overactive immune system.
AVO: RINVOQ is a once-daily pill that travels through the bloodstream, helping to reduce inflammation and give your colon lining the chance to repair from the buildup of damage.
TEXT ON SCREEN: IN CLINICAL STUDIES, RINVOQ WAS PROVEN TO HELP DELIVER:
Rapid symptom relief as early as 2 weeks*
*Based on the frequency of bowel movements and the amount of bloody stools.
Remission in 8 weeks, with many people in lasting remission even at 1 year
Visible improvement of the colon lining
AVO: In clinical studies RINVOQ was proven to help deliver rapid symptom relief, lasting remission, and visible improvement of the colon lining.
TEXT ON SCREEN:
For adults with moderate to severe UC in whom TNF blockers did not work well
Ask your gastroenterologist if RINVOQ is right for you
US-RNQG-220377
AVO: Ask your gastroenterologist if RINVOQ is right for you.
AVO and TEXT ON SCREEN:
SAFETY CONSIDERATIONS
RINVOQ may cause serious side effects, including:
- Serious infections. RINVOQ can lower your ability to fight infections. Serious infections, some fatal, occurred while taking RINVOQ, including tuberculosis (TB) and infections caused by bacteria, fungi, or viruses.
- Increased risk of death in people 50 years and older with at least 1 heart disease risk factor.
- Cancer and immune system problems. RINVOQ may increase your risk of certain cancers, including lymphoma and skin cancer. Current or past smokers are at higher risk for lymphoma and lung cancer.
- Increased risk of major cardiovascular events such as heart attack, stroke, or death in people 50 years and older with at least 1 heart disease risk factor, especially in current or past smokers.
- Blood clots, some fatal, in the veins of the legs or lungs and arteries. This occurred more often in people 50 years and older with at least 1 heart disease risk factor.
- Serious allergic reactions. Do not take if allergic to RINVOQ or any of its ingredients.
- Tears in the stomach or intestines and changes in certain laboratory test results.
TEXT ON SCREEN:
Please see additional Important Safety Information on this page.
Select Important Safety Information
RINVOQ may cause serious side effects, including:
- Serious Infections, Cancer and Immune System Problems, and Blood Clots.
- Increased risk of death in people age 50+ with at least 1 heart disease risk factor.
- Increased risk of major cardiovascular events, such as heart attack, stroke, or death in people age 50+ with at least 1 heart disease risk factor, especially in current or past smokers.
- Serious allergic reactions. Do not take if allergic to RINVOQ or its ingredients.
See full Important Safety Information below.
Set reminders
Use the App to set medication reminders and track doses.
RINVOQ results
In clinical studies, RINVOQ helped people living with UC experience remission at 8 weeks and 1 year.
Plus, RINVOQ helped deliver:
- Rapid relief from UC symptoms (fewer bowel movements and bloody stools) in as early as 2 weeks
- Powerful results
- No bowel urgency, no abdominal pain, and significantly reduced fatigue at 8 weeks
- Steroid-free remission at 1 year
- Visible colon lining repair,* even at 1 year
*Areas that were visually assessed may not represent repair of the entire colon lining.
- Long-term results
- In another study, many people were in remission, even at ~3 years†
†In a less rigorous study with data available at ~3 years, physicians and patients knew that RINVOQ was being used, which may have influenced results. Results measured in RINVOQ-treated patients who met clinical response at 8 weeks (defined by decrease in stool frequency, rectal bleeding and endoscopic improvement).
- In another study, many people were in remission, even at ~3 years†
Understanding the possible side effects of RINVOQ
Always consider the benefits and risks of taking RINVOQ and discuss with your doctor.
Get 1-to-1 support from your RINVOQ Complete Nurse Ambassador‡
Reach out when you need answers. Just call 1.800.2RINVOQ (1.800.274.6867).
‡Nurse Ambassadors are provided by AbbVie and do not work under the direction of your health care professional (HCP) or give medical advice. They are trained to direct patients to their HCP for treatment-related advice, including further referrals.
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