Psoriatic arthritis (PsA)

treatment-options

Psoriatic arthritis (PsA)

Not all PsA treatments work the same for everyone

No matter where you are in your fight against PsA, undertreating your symptoms can lead to worsening joint and skin symptoms, and further irreversible joint damage.

So if you're still experiencing PsA symptoms, it's important to work together with your rheumatologist to adjust your treatment plan.

There's no "one size fits all" solution to treating PsA

There are many medications currently available to help reduce PsA symptoms and you should discuss the risks and benefits of any treatment with your rheumatologist. Some PsA treatment options include:

Conventional  Therapies

  • Analgesics?
  • Non-steroidal anti-inflammatory drugs (NSAIDs) ?

Pain relief medications such as acetaminophen

Medications, like aspirin and ibuprofen, that help reduce pain and inflammation

  • Corticosteroids?
  • Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) ?

Used broadly to help reduce pain and inflammation for a short term. Includes topicals

Conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) is a general name for the large number of medicines, like methotrexate, that modify the course of PsA itself

Biologics are pharmaceutical products manufactured in a living system such as a microorganism or plant or animal cell

Advanced Therapies

Work by targeting a specific part of the immune system in order to reduce the inflammation seen in RA—one example of a biologic is a TNF inhibitor

Block parts of the body’s immune response in order to reduce inflammation—one example of an oral small molecule is a JAK-inhibitor

Understanding advanced therapies

Advanced therapies are used after conventional therapies. One type of advanced therapy, JAK inhibitors, are prescribed after TNF blockers.

There have been many advances in PsA treatment in recent years, with treatment options that work in different ways. Here are some PsA treatment options to consider when preparing to speak to your rheumatologist.

Janus kinase (JAK) inhibitors

How they work: Block parts of the body’s immune response in order to reduce inflammation.

RINVOQ® (upadacitinib)

1 pill every day

365 pills per year

365 pills per year

APPROVED USE

RINVOQ is used to treat adults with active psoriatic arthritis when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well or could not be tolerated. It is not known if RINVOQ is safe and effective in children with psoriatic arthritis.

XELJANZ® (tofacitinib)

1 or 2 pills every day

365-730 pills per year

365-730 pills per year

Tumor necrosis factor (TNF) blockers

How they work: Block an inflammatory protein called TNF.

CIMZIA® (certolizumab pegol)

1 injection every other week* after starting dose of 2 injections at weeks 0, 2, and 4

26 injections per year (after starter doses)

26 injections per year
(after starter doses)

ENBREL® (etanercept)

1 injection every week

52 injections per year

52 injections per year

HUMIRA® (adalimumab)

1 injection every other week

26 injections per year

26 injections per year

REMICADE® (infliximab)

1 infusion every 8 weeks* after starting 1 infusion at weeks 0, 2, and 6

6 infusions per year, (after starter doses)

6 infusions per year
(after starter doses)

Interleukin-23 (IL-23) receptor blockers

How they work: Block an inflammatory protein called IL-23.

SKYRIZI® (risankizumab-rzaa)

1 injection every 12 weeks after starting dose of 1 injection at weeks 0 and 4

4 injections per year (after starter doses)

4 injections per year
(after starter doses)

TREMFYA® (guselkumab)

1 injection every 8 weeks after starting dose of 1 injection at weeks 0 and 4

6 injections per year (after starter doses)

6 injections per year
(after starter doses)

Interleukin-17 (IL-17) receptor blockers

How they work: Block an inflammatory protein called IL-17.

COSENTYX® (secukinumab)

1 injection every 4 weeks for adults (the first 5 injections dosed every week could be considered for some)

12 injections per year (after starter doses)

12 injections per year
(after starter doses)

TALTZ® (ixekizumab)

1 injection every 4 weeks after 1 starting dose of 2 injections at week 0

12 injections per year (after starter doses)

12 injections per year
(after starter doses)

Interleukin-12 and 23 (IL-12/23) receptor blockers

How they work: Block inflammatory proteins called IL-12 and IL-23.

STELARA® (ustekinumab)

1 injection every 12 weeks for adults, after 2 starting doses of 1 injection at weeks 0 and 4 

4 injections per year (after starter doses)

4 injections per year
(after starter doses)

Phosphodiesterase-4 (PDE4) inhibitors

How they work: Inhibit an inflammatory enzyme called PDE4.

OTEZLA® (apremilast)

2 pills every day

730 pills per year

730 pills per year

*Dosing may vary at your prescriber’s discretion based on your needs and reactions.

This presentation is not intended to compare the safety, efficacy, or uses of these treatments. Please refer to each product’s full Prescribing Information for additional information.

Talk to your doctor about the risks and benefits of your treatment options. These medications should be used under the supervision of a healthcare professional. Always tell your doctor about any side effects you may be experiencing.

Have you ever been or are you currently prescribed a TNF blocker for your active PsA?

Yes, I have previously been or am currently prescribed a TNF blocker

If you’re still experiencing PsA symptoms after a TNF blocker like HUMIRA® or ENBREL®, it may be time to speak with your rheumatologist. Prepare for your visit with the Appointment Checklist >

HUMIRA® is a registered trademark of AbbVie Inc. ENBREL® (etanercept) is a registered trademark of Immunex Corporation in the US.

No, I have not been prescribed a TNF blocker

If your PsA symptoms are uncontrolled, finding a PsA treatment that’s right for you takes focusing on goals and working with a rheumatologist.

Time for a change in your treatment plan?

Deciding to change your treatment plan is never easy, but neither is living with PsA joint and skin symptoms.

Learn about RINVOQ

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